About this event

  • Date and time Wed 10 Mar 2021 from 6:00pm to 7:00pm
  • Location Online
  • Organised by Vascular, Lipid and Metabolic Medicine Section

Associate Professor Lisa Heather, British Heart Foundation Fellow, will explore the heart’s energy requirements and the fine balance between free fatty acid (FFA) delivery and utilisation for optimal cardiac function. The heart’s requirement for ATP (the energy currency) to support contractile functions cannot be underestimated. Energy availability (supply) and workload (demand) are in continual flux, resulting in large fluctuations in physiological demands. 

CPD learning accredited. 

This webinar will cover:

  • The basic principles of energy metabolism in the heart to support contractile function.
  • Comprehension and understanding that the heart generates a large proportion of its energy from FFA derived mitochondrial oxidative phosphorylation to support contractile function.  
  • The underlying factors that alter FFA supply and delivery to the heart.  
  • The impact of FFA modifying treatments on contractile function. 

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Key speakers

Prof Lisa Heather

Associate Professor Lisa Heather

Associate Professor, British Heart Foundation Fellow, University of Oxford, UK


Speaker's biography

Professor Heather's research revolves around metabolism and the heart – understanding why metabolism is important and what the consequences are when it goes wrong.

Her passion for metabolism began during her undergraduate degree in Medical Biochemistry at the University of Surrey. She loved the way everything fitted together into this complex jigsaw, which in many ways resembled the London Underground map. And just like a public transport network, if something goes wrong with one enzyme or pathway, the whole system can either adapt or grind to a halt.   

Lisa joined the Department in 2003 as a DPhil student of Professor Kieran Clarke. Her doctoral research investigated the role of abnormal substrate metabolism in the development of cardiac hypertrophy. Her subsequent post-doctoral research focused on the role of mitochondrial metabolism in cardiac disease progression. 

In 2011 she was awarded a Diabetes UK RD Lawrence Fellowship, to study the role of hypoxia and metabolism in the type 2 diabetic heart. Heart disease is the leading cause of mortality in patients with type 2 diabetes, and patients have increased incidence of, and decreased recovery following myocardial infarction.  

In 2018 she was awarded a British Heart Foundation Intermediate Fellowship, to study why fat accumulation in the diabetic heart is such a bad thing. She is currently studying what fats can do to the function of the cardiomyocyte, and how they might be signalling to activate deleterious processes.   


View the programme

Welcome and introduction

Dr James Hobkirk, Lecturer, Human Physiology and Honorary Medical Scientist, University of Hull

The 'Goldilocks zone’ of fatty acid metabolism and cardiac function

Associate Professor Lisa Heather, British Heart Foundation Fellow, University of Oxford

Close of webinar



Disclaimer: All views expressed in this webinar are of the speakers themselves and not of the RSM nor the speaker's organisations.

Special rates for difficult times 
The RSM wishes to offer healthcare professionals continued learning opportunities during the coronavirus pandemic. The RSM’s ​weekly COVID-19 Series ​webinars remain free of charge, while there will be small charges to register for other online education. These fees will enable the RSM to continue its programme of activities and will apply during the course of the pandemic.

Registration for this webinar will close 2 hours prior to the start time. You will receive the webinar link 2 hours before the meeting. Late registrations will not be accepted.

All webinars will be available for registered delegates 30 days after on Zoom. The link will be sent 24 hours after the webinar takes place. 

This webinar will be recorded and stored by the Royal Society of Medicine and may be  distributed  in future on various internet channels. 

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