About this event

  • Date and time Wed 12 May 2021 from 6:00pm to 7:00pm
  • Location Online
  • Organised by Vascular, Lipid and Metabolic Medicine Section

This webinar will explore and provide an overview of mitochondrial substrate utilization in the healthy and diseased heart.

Professor Adam R. Wende, PhD., FAHA, Division of Molecular and Cellular Pathology, The University of Alabama at Birmingham, USA, will examine the impact of altering glucose delivery in either the context of physiologic stress such as exercise versus pathologic conditions, pressure-overload induced heart failure, or diabetic cardiomyopathy.

The lecture will include examples of changes in metabolism, protein function, and gene expression. The knowledge gained from this talk will allow better understanding between the impact of changes in systemic metabolism (i.e. diabetes and hyperglycaemia) and heart failure (e.g. hypertrophy, contractile dysfunction, and disrupted cellular signalling). 

The lecture will be followed by a Q&A session. 

You will learn about:

  • The impact of changes in cardiac substrate delivery, both at the level of energetic demand (i.e. ATP) as well as signalling. 
  • How the heart uses glucose as both fuel as well as a signal to mitochondria and the nucleus.
  • The therapeutic potential as well as caveats to modifying cardiac glucose utilization in the context of heart failure.

This webinar is part of a monthly series that looks at the mitochondrial, metabolic and lipidomic aspects of the heart. Previous webinars include The 'Goldilocks zone’ of fatty acid metabolism and cardiac function, originally broadcast in March, and The role of lipidomics in understanding fatty acid metabolic dysregulation in human heart failure, broadcast in April 

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Key speakers

Adam Wende

Professor Adam R. Wende, PhD., FAHA

Assistant Professor, Division of Molecular and Cellular Pathology, The University of Alabama at Birmingham, USA

Speaker's biography

Since 2000, Dr Wende has explored the regulation of metabolism and mitochondrial function with a specific focus on glucose utilization in heart and muscle. He completed his Ph.D. training in the Cardiology Department as part of the Division of Biology and Biomedical Sciences at Washington University in St. Louis, MO studying PGC-1a transcriptional regulation with Dr Daniel P. Kelly. His postdoctoral training followed at the University of Utah with Dr E. Dale Abel examining diabetes impact on the heart through upstream regulation by cellular signalling and the resulting changes in mitochondrial physiology.


In August of 2013, he joined the faculty at The University of Alabama at Birmingham in the Division of Molecular and Cellular Pathology where he is now a tenured Associate Professor. His work has been funded by the American Heart Association, the JDRF, and the NIH. His independent research program through use of transgenic and diabetes mouse models to identify molecular and genetic mechanisms of glucose-mediated control of mitochondrial function.


Specifically, work in the laboratory has two primary goals: 1) to determine the role of metabolic substrate switching in the hearts of individuals with diabetes or heart failure, and 2) to define the role of cellular glucose delivery on post-translational regulation of mitochondrial enzyme activity and epigenetic regulation of gene expression that together may lead to the development of diabetic cardiomyopathy.


View the programme

Welcome and introduction

Dr James Hobkirk, Lecturer, Human Physiology and Honorary Medical Scientist, University of Hull

Mitochondrial substrate flexibility in the heart – The sweet side of metabolism

Professor Adam R. Wende, PhD., FAHA, Assistant Professor, Division of Molecular and Cellular Pathology, The University of Alabama at Birmingham, USA

Question and answer session



Disclaimer: All views expressed in this webinar are of the speakers themselves and not of the RSM nor the speaker's organisations.

Special rates for difficult times 
The RSM wishes to offer healthcare professionals continued learning opportunities during the coronavirus pandemic. The RSM’s ​weekly COVID-19 Series ​webinars remain free of charge, while there will be small charges to register for other online education. These fees will enable the RSM to continue its programme of activities and will apply during the course of the pandemic.

Registration for this webinar will close 2 hours prior to the start time. You will receive the webinar link 2 hours before the meeting. Late registrations will not be accepted.

All webinars will be available for registered delegates 30 days after on Zoom. The link will be sent 24 hours after the webinar takes place. 

This webinar will be recorded and stored by the Royal Society of Medicine and may be  distributed  in future on various internet channels.