Horizon scanning in intraocular inflammation

Professor Alastair Denniston is a Consultant Ophthalmologist specialising in uveitis at University Hospitals Birmingham NHS Foundation Trust, one of the UK’s largest acute healthcare organisations. His work focuses on use of health data research and the application of digital healthcare (including artificial intelligence) to improve patient care in the ‘real world’. Professor Denniston leads a team committed to ensuring that the best innovation within the broad field of ‘artificial intelligence’ is translated safely, efficiently, equitably and inclusively to patients. This includes improving the design and reporting of clinical trials in this area (CONSORT-AI and SPIRIT-AI), highlighting issues of representativeness including the risk of health data poverty; developing tools to support safe deployment (including validation datasets); and working with regulators and other stake-holder groups to support the best of these innovations right through the implementation pathway to routine patient care and public health. Professor Denniston has a particular interest in the use of routinely collected data and digital innovation to tackle sight-threatening disease. He is the Director of INSIGHT, the UK’s Health Data Research Hub for Eye Health which is focused on eye disease and its application to wider health, including diabetes and dementia (unlocking the power of ‘oculomics’). INSIGHT enables the use of anonymised large-scale data and advanced analytics, including artificial intelligence, to develop new insights in disease detection, diagnosis, treatments and personalised healthcare. Professor Denniston is a Member of the UK Government’s Regulatory Horizons Council, AI Theme Lead for the Centre for Regulatory Science and Innovation (Birmingham, UK), and part of the UK’s Biomedical Research Centre for Ophthalmology (Moorfields Eye Hospital/UCL).

Professor Carlos Pavesio is Professor of Ocular Inflammation and Infection at University College London in London and Consultant Ophthalmic Surgeon at Moorfields Eye Hospital, London, UK. He was the Medical Retina Service Director between 2008 and 2016 and is currently Co-Director of the Uveitis Service at Moorfields. He is the Uveitis theme leader for the Biomedical Research Centre, Institute of Ophthalmology, London.  He is also Director of the Fellowship Programme at Moorfields Eye Hospital and Chairman of the Infection Control Committee. Professor Pavesio is a Member of many international ophthalmological societies, including IOIS (International Ocular Inflammation Society), IUSG (International Uveitis Study Group). He was a board member for the SOE and EUPO (European Union of Professors of Ophthalmology).  For over 10 years he has been the organiser of the Uveitis Programme for EURETINA and SOE, apart from having organised more than 10 International Uveitis Courses, both in the UK and abroad. He has given more than 300 lectures both in the UK and Internationally. He was visiting Professor of Ophthalmology in New Zealand in 2009 and HMDP Visiting Expert in Ophthalmology – Uveitis, Intraocular Inflammation, Medical Retina in Singapore in 2014. He has also been a faculty member for the Cole Eye Institute Uveitis Course held in Cleveland, USA. Professor Pavesio is the Editor-in-Chief for the Journal of Ophthalmic Inflammation and Infection and a member of the editorial board of the British Journal of Ophthalmology, Ocular Immunology and Inflammation, International Ophthalmology, and Journal of Ocular Infections and Inflammation and Ophthalmology. He has co-edited five books in Ophthalmology and has authored more than 30 book chapters. He has over 200 peer-reviewed publications in the field.