Professor John Blenis
Professor of Pharmacology, Cornell University, New York, USA: S6K1 and its role in mediating mTORC1-dependent regulation of cellular metabolism and mRNA processing
About this event
- Date and time Tue 9 May 2023 from 11:50am to 11 May 2023 at 5:00pm
- Location Online
- Organised by Oncology
This conference will, for the first time, gather the most notable world specialists in the field of S6 kinase research to present their latest findings.
S6 kinases are key intracellular signalling molecules involved in critical processes for normal and disease states including malignancy. They are members of the ATG kinase superfamily and are downstream effectors of the PI3 kinase, mTOR and ERK pathways which are involved in cancer. In humans, there are 3 subgroups of S6Ks: (S6K1 and 2), the RSKs (RSK1 to 4) and the MSKs (MSK1 and 2). While sharing a high degree of homology, they regulate different and sometimes contradictory biological processes. A lack of appreciation for their non-overlapping functions and of specific and selective clinically viable inhibitors have so far limited their targeting in clinical practice.
During this event, we will unveil our new understanding of the selectivity of these enzymes in driving biological processes and disease with a focus on cancer. We will examine the latest efforts in designing inhibitors targeting the involved pathways and consider how this might be applied to clinical practice.
This 3-day conference will be of interest to all researchers working on cell signalling, cancer biology, development as well as clinical practitioners involved in diseases where S6 kinases play a role, such as cancer. The event will also be an opportunity to network with the major players in the field and for young and early-career scientists to present their data in the form of posters or short oral presentations.
Participants will be able to:
- Know about the latest developments on the role of the S6K2 pathway in pathology and the therapeutic potential of targeting it in cancer
- Gain the latest understanding of the roles of RSK kinases in regulating the cancer phenotype
- Have an in-depth understanding of the role of S6K and RSK kinases in whole organism homeostasis
This webinar is available for on-demand viewing. The webinar recording will be available for registered event participants up to 60 days after the live webinar broadcast via Zoom. The link will be sent 24 hours after the webinar takes place.
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We would like to thank our sponsor the British Association for Cancer Research (BACR) for their support of this meeting. Please note that the scientific programme and content has not been influenced in any way by the sponsor.
Key speakers
Professor Deborah Lannigan
Professor of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, USA: RSK Regulation of Estrogen Homeostasis
Dr Mario Pende
Directeur de Recherche 1, Inserm, Université Paris Cité: Pathophysiology of cell size control by S6 kinase
Agenda
View the programme
Tuesday 9 May 2023 - Day 1
Welcome and introduction
Dr Olivier E. Pardo, Imperial College London
Enhanced Sestrin expression through Tanshinone 2A treatment improves PI3K-dependent inhibition of glioma growth
Professor Robin Williams, Royal Holloway, University of London
p70S6K in ovarian cancer: Functions beyond translation
Professor Alice Wong, University of Hong Kong, China
CoAation in the regulation of S6K pathways
Professor Ivan Gout, University College London
Comfort break
Pathophysiology of cell size control by S6 kinase
Professor Mario Pende, Faculté de Médecine Paris Descartes, France
RSK4 in the regulation of drug resistance and metastasis in lung and bladder cancer
Dr Olivier E. Pardo
hnRNPA1 as a downstream target of S6K2 regulates export and translation of target mRNAs
Professor Michael J Seckl, Imperial College London
Comfort break
RSK2 drives cancer cell migration and invasion in part through phosphorylation and activation of ARHGEF12 (LARG)
Dr Joe Ramos, Louisiana Cancer Research Center, USA
Panel discussion
Close of meeting
Wednesday 10 May 2023 - Day 2
Welcome and introduction
Asymmetric dimethylation of Ribosomal S6K2 regulates its cellular localisation and pro-survival function
Professor Mahmoud Khalil, University of Alexandria, Egypt
Design of selective covalent S6K2 inhibitors
Dr Matthias Gehringer, Eberhard Karls Universität Tübingen, Germany
RSK4 regulates a pseudo-hypoxic response in lung cancer cells
Dr Sotirios Zervopoulos, Imperial College London
Comfort break
ARK5 regulates subcellular localization of hnRNP A1 during hypertonic stress
Professor Martin Holcik, Carleton University, Canada
The p90 Ribosomal S6 Kinase family promotes prostate cancer progression via androgen receptor activation
Dr Filippo Prischi, University of Essex
S6K1 and its role in mediating mTORC1-dependent regulation of cellular metabolism and mRNA processing
Professor Jon Blenis, Cornell University, USA
Comfort break
RSK control of myosin and adhesions in cell migration
Professor Michelle Mendoza, University of Utah, USA
Panel discussion
Close of meeting
Thursday 11 May 2023 - Day 3
Welcome and introduction
Increased fidelity of protein synthesis extends lifespan
Dr Ivana Bjedov, University College London
Long-term mouse models and new methods and tools for RSK/S6K research
Dr Morten Frödin, University of Copenhagen, Denmark
Comfort break
Unexpected regulation of mTORC1/S6K signaling by alkaline intracellular pH
Dr Diane Fingar, University of Michigan Medical School, USA
RSK Regulation of estrogen homeostasis
Professor Deborah Lannigan, Vanderbilt University, USA
Panel discussion
Closing remarks
Dr Olivier E. Pardo, Imperial College London
Close of meeting
Sponsors
Location
Online
Registration for this event will close at 1:00am on Sunday 7 May 2023. Late registrations will not be accepted.
Disclaimer:
- The agenda is subject to change at any time
- If the event is recorded, we are only able to share presentations that we have received permission to share. There is no guarantee that all sessions will be available after the event, this is at the presenter’s and RSM discretion.
- All views expressed at this event are of the speakers themselves and not of the Royal Society of Medicine, nor the speaker's organisations.
- This event will be recorded and stored by the Royal Society of Medicine and may be distributed in future on various internet channels.
