About this event

  • Date and time Tue 9 May 2023 from 11:50am to 11 May 2023 at 5:00pm
  • Location Online
  • Organised by Oncology

 This conference will, for the first time, gather the most notable world specialists in the field of S6 kinase research to present their latest findings.

S6 kinases are key intracellular signalling molecules involved in critical processes for normal and disease states including malignancy. They are members of the ATG kinase superfamily and are downstream effectors of the PI3 kinase, mTOR and ERK pathways which are involved in cancer. In humans, there are 3 subgroups of S6Ks: (S6K1 and 2), the RSKs (RSK1 to 4) and the MSKs (MSK1 and 2). While sharing a high degree of homology, they regulate different and sometimes contradictory biological processes. A lack of appreciation for their non-overlapping functions and of specific and selective clinically viable inhibitors have so far limited their targeting in clinical practice.

During this event, we will unveil our new understanding of the selectivity of these enzymes in driving biological processes and disease with a focus on cancer. We will examine the latest efforts in designing inhibitors targeting the involved pathways and consider how this might be applied to clinical practice.

This 3-day conference will be of interest to all researchers working on cell signalling, cancer biology, development as well as clinical practitioners involved in diseases where S6 kinases play a role, such as cancer. The event will also be an opportunity to network with the major players in the field and for young and early-career scientists to present their data in the form of posters or short oral presentations.

Participants will be able to:

  • Know about the latest developments on the role of the S6K2 pathway in pathology and the therapeutic potential of targeting it in cancer
  • Gain the latest understanding of the roles of RSK kinases in regulating the cancer phenotype
  • Have an in-depth understanding of the role of S6K and RSK kinases in whole organism homeostasis

 

Follow us on: 

Facebook 
Instagram 
LinkedIn 
Twitter 
YouTube 

Tickets

Standard pricing available until 08 May 2023.

Multiday discount

Save 10% if you book 2 days and 15% if you book 3 days. This discount will automatically applied at checkout.

Member

RSM Fellow
Day 1 Day 2 Day 3
£24.00 Day 1
£24.00 Day 2
£24.00 Day 3
RSM Associate
Day 1 Day 2 Day 3
£18.00 Day 1
£18.00 Day 2
£18.00 Day 3
RSM Retired Fellow
Day 1 Day 2 Day 3
£18.00 Day 1
£18.00 Day 2
£18.00 Day 3
RSM Trainee
Day 1 Day 2 Day 3
£18.00 Day 1
£18.00 Day 2
£18.00 Day 3
RSM Student
Day 1 Day 2 Day 3
£12.00 Day 1
£12.00 Day 2
£12.00 Day 3

Non - Member

Consultant / GP / SAS Doctors
Day 1 Day 2 Day 3
£44.00 Day 1
£44.00 Day 2
£44.00 Day 3
AHP / Nurse / Midwife
Day 1 Day 2 Day 3
£33.00 Day 1
£33.00 Day 2
£33.00 Day 3
Non Healthcare Professional
Day 1 Day 2 Day 3
£33.00 Day 1
£33.00 Day 2
£33.00 Day 3
Trainee
Day 1 Day 2 Day 3
£33.00 Day 1
£33.00 Day 2
£33.00 Day 3
Student
Day 1 Day 2 Day 3
£22.00 Day 1
£22.00 Day 2
£22.00 Day 3

Key speakers

Professor John Blenis

Professor of Pharmacology, Cornell University, New York, USA: S6K1 and its role in mediating mTORC1-dependent regulation of cellular metabolism and mRNA processing

Professor Deborah Lannigan

Professor of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, USA: RSK Regulation of Estrogen Homeostasis

Professor Philippe Roux

Université de Montréal, Montreal, Canada: Identification and characterization of novel AGC kinase substrates

Dr Mario Pende

Directeur de Recherche 2, Faculté de Médecine Paris Descartes, Paris, France: Pathophysiology of cell size control by S6 kinase

Agenda

View the programme

Tuesday 9 May 2023 - Day 1

Welcome and introduction

Dr Olivier E. Pardo, Imperial College

mTORC1 and the control of protein synthesis

Prof Chris Proud, University of Adelaide

p70S6K in ovarian cancer: Functions beyond translation

Prof Alice Wong, University of Hong Kong

S6Ks and ageing and metabolism

Prof Dominic J Withers, Imperial College London

Comfort break
Pathophysiology of cell size control by S6 kinase

Prof Mario Pende, Faculté de Médecine Paris Descartes

S6K1 and its role in mediating mTORC1-dependent regulation of cellular metabolism and mRNA processing

Prof Jon Blenis, Cornell University

Identification and characterization of novel AGC kinase substrates

Prof Philippe P. Roux, Université de Montréal

Comfort break
Short presentation from abstracts
Panel discussion
Close of meeting

Wednesday 10 May 2023 - Day 2

Welcome and introduction
hnRNPA1 as a downstream target of S6K2 regulates export and translation of target mRNAs

Prof Michael J Seckl, Imperial College London

Design of selective covalent S6K2 inhibitors

Dr Matthias Gehringer, Eberhard Karls Universität Tübingen

Short presentation from abstracts
Short presentation from abstracts
Comfort break
ARK5 regulates subcellular localization of hnRNP A1 during hypertonic stress

Prof Martin Holcik, Carleton University

The p90 Ribosomal S6 Kinase family promotes prostate cancer progression via androgen receptor activation

Dr Filippo Prischi, University of Essex

RSK4 in the regulation of drug resistance, metastasis and metabolism of lung cancer

Dr Olivier E. Pardo, Imperial College London

Comfort break
RSK control of myosin and adhesions in cell migration

Prof Michelle Mendoza, The University of Utah

Panel discussion
Electronic poster session
Close of meeting

Thursday 11 May 2023 - Day 3

Welcome and introduction
Electronic poster session
CoAation in the regulation of S6K pathways

Prof Ivan Gout, University College London

Short presentation from abstracts
Short presentation from abstracts
Comfort break
Long-term mouse models and new methods and tools for RSK/S6K research

Dr Morten Frödin, University of Copenhagen

TBC

Dr Diane Fingar, University of Michigan Medical School

RSK Regulation of estrogen homeostasis

Prof Deborah Lannigan, Vanderbilt University

Panel discussion
Closing remarks

Dr Olivier E. Pardo, Imperial College

Close of meeting

Location

Online

Registration for this event will close at 1:00am on Sunday 7 May 2023. Late registrations will not be accepted.

Disclaimer:

  • The agenda is subject to change at any time
  • If the event is recorded, we are only able to share presentations that we have received permission to share. There is no guarantee that all sessions will be available after the event, this is at the presenter’s and RSM discretion.
  • All views expressed at this event are of the speakers themselves and not of the Royal Society of Medicine, nor the speaker's organisations.
  • This event will be recorded and stored by the Royal Society of Medicine and may be distributed in future on various internet channels.
1 Wimpole Street venue hire

Venue hire

The RSM's venue space, 1 Wimpole Street is located in central London and offers event spaces for 2 to 300 people. The diverse range of services includes rooms for hybrid and live-streamed conferences, meetings and training or social events such as anniversary or birthday celebrations. 1 Wimpole Street also has a civil wedding licence.

Contact us today on 020 7290 2979.

Find out more