AKI frontiers 2019: Research, innovation and improvements in acute kidney injury

Dr Bagshaw is a professor and chair, of the department of critical care medicine, faculty of medicine and dentistry, at the University of Alberta. He trained at the University of Calgary (internal medicine, critical care medicine, master of science epidemiology) and the Austin Hospital (critical care nephrology) in Melbourne, Australia.

Dr Bagshaw is supported by a Canada Research Chair in critical care nephrology. he has research expertise in clinical epidemiology, clinical trials and health services research. His research focuses on acute kidney injury, vulnerable populations (e.g., elderly, frail), intensive care unit organization and capacity. He has published over 350 peer-reviewed papers, numerous book chapters, and peer-reviewed for over 30 medical journals. Dr Bagshaw is a member of several organizations including the Canadian Critical Care Society, Canadian Critical Care Trials Group, and the Acute Disease Quality Initiative.

Dr Emmanuel A. Burdmann is associate professor in the division of nephrology, department of internal medicine, at the University of São Paulo Medical School, Brazil. He obtained his medical and PhD. degree from the University of São Paulo, where he also completed his fellowship. He did his post-doctoral fellowship with Professor William Bennett at the Oregon Health Sciences University. The member of numerous scientific societies, he is the past-president of both the Latin American Society of Nephrology and Hypertension and the Brazilian Society of Nephrology, and has served on the council of the International Society of Nephrology, the Kidney Disease Improving Global Outcomes (KDIGO®) executive committee and acted as a co-director of the 0by25 Program of the International Society of Nephrology.

Dr Burdmann was involved in the development of the KDIGO® clinical practice guidelines on acute kidney injury, is an editorial board member for several journals including the Brazilian Journal of Nephrology, Kidney International, PLOs One and American Journal of Kidney Diseases, and is the author or co-author of over 200 journal articles and book chapters.

Patrick Murray is a full professor of clinical pharmacology in University College Dublin (UCD), and a consultant physician (clinical pharmacologist and nephrologist) in Dublin, Ireland. He received his medical education at UCD. Following his internship at the Mater Misericordiae University Hospital (MMUH), he completed a residency in internal medicine at Hennepin County Medical Center in Minneapolis, USA. He completed fellowship training programs in nephrology, critical care medicine, and clinical pharmacology at the University of Chicago Hospitals (UCH), USA. He practised as an intensivist, nephrologist, and clinical pharmacologist at UCH from 1996–2008, and was a professor at the University of Chicago Pritzker School of Medicine. He served as the fellowship training program director in nephrology, also directing the Acute Dialysis Service. He has a longstanding interest in research and education to improve the prevention, diagnosis, and therapy of acute kidney injury (AKI) and nephrotoxicity, and the pharmacotherapy of patients with kidney disease. He is a member of several international consensus groups that have produced guidelines for research and practice in the field of AKI (Acute Dialysis Quality Initiative (ADQI), Acute Kidney Injury Network (AKIN), Kidney Disease Outcomes Quality Initiative (KDOQI)).

Since 2008, he has been the inaugural professor of clinical pharmacology at UCD, and a consultant in nephrology and clinical pharmacology at MMUH and at St. Vincent’s University Hospital. He is chair of the MMUH drugs and therapeutics committee. He is the clinical director of the UCD Clinical Research Centre. In 2012, he was appointed the director of the Dublin Centre for Clinical Research (DCCR) Consortium Network, and also the clinical director of the Irish Clinical Research Infrastructure Network (ICRIN). From December 2012 through June 2018, he served as the dean and head of the School of Medicine at UCD.

Dr Wilson grew up in Connecticut, before attending Harvard College where he graduated with a degree in biochemistry. He then attended medical school at Columbia College of Physicians and Surgeons, before completing his internship, residency, and fellowship at the University of Pennsylvania. In 2012, he received a masters degree in clinical epidemiology, which has informed his research ever since. At Yale since 2014, his goal is use patient-level data and advanced analytics to personalize medicine to each individual patient.

Dr Wilson uses epidemiologic and translational research methods to characterize predictors of outcomes in patients with both chronic kidney disease and acute kidney injury. In addition, he uses advanced machine-learning techniques to identify which patients are most likely to respond to a given intervention. These models can reduce the number of individuals exposed to a drug or intervention unnecessarily, reducing adverse events, and lowering costs.