Professor Paul Mischel
Professor and Vice-Chair for Research, Department of Pathology, Stanford University School of Medicine, USA
Paul Mischel is a Professor and Vice Chair for Research for the Department of Pathology, Stanford University School of Medicine and Institute Scholar, Stanford ChEM-H. The Mischel lab has made a series of seminal discoveries that identified ecDNA (extrachromosomal DNA) as a driving force of cancer heterogeneity and therapeutic resistance. This research has provided a paradigm shift in understanding the fundamental mechanisms of oncogene amplification, intratumoural heterogeneity, and the spatial organization of altered tumour genomes. Bridging cancer genetics, signal transduction and cellular metabolism, research from the lab has provided a new understanding of the fundamental mechanisms of oncogene amplification and the spatial organization of altered tumour genomes, launching a new area of cancer research that links circular architecture with tumour pathogenesis.