Drug discovery and development in the 21st century

Unfortunately this event has been cancelled

Thursday 4 December 2008

Venue: The Royal Society of Medicine, 1 Wimpole Street, London, W1G 0AE

organised by the Royal Society of Medicine in association with FRAME and The British Pharmacological Society

Over the past few decades, there have been dramatic advances in the application of the molecular sciences to biology and medicine. One consequence of this is that post-genomic methodologies, cell culture systems, tissue engineering, biophysical techniques and computer-based procedures are increasingly applied within the sphere of drug discovery and development.

Animal models have traditionally been used to select the most suitable drug candidates for human studies. However, the relevance of paradigms based on animal pharmacotoxicology and animal disease models is now constantly being questioned, not least because of the emergence of gene-, cell- and human-specific protein therapeutics and medical nanotechnologies. These developments have highlighted the sometimes subtle, but often crucial, differences between human and animal responses to pharmacological intervention, and make the requirement for drug testing based on human systems an increasing necessity.

The aims of this symposium are to encourage dialogue between stakeholders and decision makers, with a view to identifying the future roles of scientifically-advanced and more-appropriate alternatives to animal research and testing in drug discovery and development.

Registration Details:
Fellow: £135
BPS Member: £135
FRAME Member: £135
Associate: £105
Trainee - Fellow: £95
Retired Fellow: £95
Student Members: £45
Nurse: £130
Allied Health Professional: £130
Non-Fellow: £170
Trainee: £130
Student: £60

CPD: 5 credits



9.15 am

Registration and coffee

9.45 am

Welcome address
Dr David Misselbrook, Dean, RSM & Professor Michael Balls, Chairman of the FRAME Trustees

Session One -
Chair: Professor David Kendall, University of Nottingham

10.00 am

The need for new approaches in regulatory pharmacotoxicology
TBC

10.30 am

Questions

10.40 am

The promise of the emerging new technologies
Professor Munir Piromohamed, University of Liverpool

11.10 am

Questions

11.20 am

Coffee break

SESSION TWO - New Technologies
Chair: Dr Vicky Robinson, NC3Rs, London

11.50 am

Breakthroughs in tissue culture technologies
Dr Uwe Marx, ProBioGen AG, Berlin, Germany

12.20 pm

Questions

12.30 pm

The exploitation of computational drug development
Dr J G Vinter, Cresset Biomolecular Discovery

1.00 pm

Questions

1.10 pm

Lunch break

SESSION THREE - Personalised medicines
Chair: Dr Nirmala Bhogal, FRAME

2.15 pm

Efficacy vs. risk of nanotechnologies in medicine
Professor Kostas Kostarelos, London School of Pharmacy,
University of London

2.55 pm

The use of integrated biological systems
Dr Paul Dobson, Research Associate, Manchester Interdisciplinary Biocentre, The University of Manchester

3.25 pm

Question

SESSION FOUR - The future
Chair: Sir Gordon Duff, Section of Molecular Medicine, University of Sheffield

3.55 pm

Translation of new technologies to clinical management
Professor Paul M. Matthews, Vice-President for Imaging; Head, GSK Clinical Imaging Centre, Drug Discovery, GlaxoSmithKline

4.25 pm

Questions

4.35 pm

How can the potential of the new technologies be realised?
TBC

5.05 pm

Personal reflections on the day
Professor Denis Noble, University of Oxford

5.30 pm

Close of meeting and drinks reception

Related information

Contact:

Events Co-ordinator:
Sinem Göçmen
Tel: +44 (0) 20 7290 3856
Fax: +44 (0) 20 7290 2989

Sponsorship Information:
Sharon Sole
Tel: +44 (0) 20 7290 3848
Fax: +44 (0) 20 7290 2989

Media Information:
Rosalind Dewar
Tel: +44 (0) 1580 764713
Mobile: +44 (0)7785 182732