Conference - The Royal Society of Medicine

9th Jenner Glycobiology and Medicine Symposium

Sunday - Tuesday 13 - 15 September 2009

Venue: Académie Royale de Médecine de Belgique

organised by the Royal Society of Medicine in association with Department of Microbiology and Immunology Rega Institute for Medical Research Catholic University of Leuven, Belgium

Participating Sections:
Clinical Immunology & Allergy Section

We are most grateful to

for supporting this conference.

This meeting is held at: Koninklijke Academie voor Geneeskunde van België - Académie Royale de Médecine de Belgique, a historic institution created under the reign of Leopold the 1st, through a royal order in 1841. For more information please visit: http://www.armb.be

The objectives of the symposium are:
- To advance our understanding of the impact of glycosylation to all areas of medicine
- To promote new research activities by bringing together scientists and clinicians from different disciplines
- To encourage more young scientists to participate and take up research in this area
- To encourage closer networking between academia and commerce

This meeting is organised by:
Professor John Axford, Director the Sir Joseph Hotung Centre for Musculoskeletal Disorder St George's University of London and NHS Trust; Ms Azita Alavi, Associate Research Fellow, The Sir Joseph Hotung Centre for Musculoskeletal Disorders;
Professor Oliver Fitzgerald, Dublin; Dr Claudine Kieda, Research Director CNRS, France; Professor Ghislain Opdenakker, Rega Institute, University of Leuven, Belgium;
Professor Pauline M. Rudd, NIBRT, University College Dublin, Ireland; Dr Irma Van Die, VU University Medical Centre, Amsterdam, The Netherlands.

Registration Details:
1 Day Fellow: £180
1 day Non Fellow: £215
1 day - Allied Health Professional: £125
1 day Student Member RSM/BACR: £105
1 day Student: £125
1 day RSM Trainee: £130
1 day - Trainee – Non Fellow: £155
3 day Fellow: £450
3 day Non Fellow: £500
3 Day Student: £310
3 Day Trainee: £400
3 day Allied Health Professional: £310
3 day Student Member: £230
3 day Trainee Fellow: £350
Early 3 Days Student Non Fellow: £280

CPD: 14 credits

Call for abstracts. [PDF 64k]

	For a list of suggested hotels download this document: Hotel information. [PDF 84k]
	For more details on travelling and accommodation, please visit the Belgian Tourist Office: http://www.visitbelgium.com/
	Programme
Sunday 13 September 2009
Session 1: introduction
Chair: Prof John Axford, St George's University of London, Director of the Sir Joseph Hotung Centre for Musculoskeletal Disorders London, UK
12.00 pm	Registration with lunch and posters viewing
1.00 pm	Welcome and introduction
	Prof John Axford, St George's University of London, Director of the Sir Joseph Hotung Centre for Musculoskeletal Disorders London, UK
1.15 pm	'The glory of glycobiology is yours'
	Prof Ghislain Opdenakker, Head of the Department of Microbiology, Rega Institute, University of Leuven, Belgium
Session 2: Glycobiology of innate and acquired immunity
Chair: Chairs: Dr Irma Van Die, VU University Medical Centre, Amsterdam, The Netherlands
2.15 pm	Introduction
	Dr Irma Van Die, VU University Medical Centre, Amsterdam, The Netherlands
2.30 pm	Mechanisms for galectin-mediated immuno-regulation
	Dr. Richard D. Cummings, William Patterson Timmie Professor and Chair Department of Biochemistry, Emory University School of Medicine, Atlanta, USA
3.00 pm	Siglecs as positive and negative regulators of the immune system
	Prof Paul Crocker, Division of Cell Biology and Immunology, Wellcome Trust Biocentre, University of Dundee, UK
3.30 pm	Oral poster presentation: The design of GAG based glycoinhibitors of chemokine
	Guillaume Collet, Universite d' Orleans, France
3.45 pm	Discussion
4.00 pm	Tea and coffee break
4.30 pm	Glycan-induced granuloma formation in schistosome infection
	Dr Ron Hokke, Centre of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands
5.00 pm	Oral poster presentation: Dendritic cells previously exposed to mannan-binding lectin (MBL) enhance cytokine production in allogenic mononuclear cell cultures
	David Kilpatrick, Scottish National Blood Transfusion Service, Scotland
5.15 pm	Oral poster presentation: Schistosoma mansoni adult worm glycolipids induce maturation of human monocyte-derived dendritic cells
	Caroline Van Stijn, VU Medical Centre, Amsterdam, Netherlands
5.30 pm	Discussion and completion of evaluation forms
5.40 pm	End of day with poster viewing
8.00 pm	Dinner, preceded by tour of the Senate
Monday 14 September 2009
8.45 am	Registration
Session 3: Glycosylation and human disease
Chair: Dr Claudine Kieda, Research Director, National Centre for Scientific Research, France
9.00 am	Introduction
	Dr Claudine Kieda, Research Director, National Centre for Scientific Research, France
9.15 am	New insights into the Congenital Disorders of Glycosylation
	Dr François Foulquier, CNRS, Structural and Functional Glycobiology Unit, University of Lille, France
9.45 am	GD3 synthase over-expression enhances proliferation and migration of MDA-MB-231 breast cancer cells
	Prof Philippe Delannoy, Structural and Functional Glycobiology Unit Sciences and Technology University of Lille, France
10.15 am	Oral poster presentation: Discovery of an antibody in patients with liver disease that promotes bacterial growth and is associated with markers of endtoxin exposure
	Anand Mehta, Drexel University College of Medicine, Doylestown
10.30 am	Discussion
10.40 am	Tea and coffee break
11.10 am	Lumican inhibits B16F1 melanoma cell lung metastasis
	Prof Stéphane Bréillon, Laboratory of Medical Biochemistry and Molecular Biologye, Medical Faculty of Reims, France
11.40 am	Oral poster presentation: Deficiency of Dol-P-Man synthase subunit DPM3 bridges the congenital disorders of glycosylation with the dystroglycanopathies
	Dirk J Lefeber, Nijmegen Medical Centre, Netherlands
11.55 am	Oral poster presentation: Serum N-Glycan profiling as a method to monitor response to diet liberalisation in galactosemia
	Jennifer Byrne, University College Dublin
12.10 pm	Discussion
12.20 pm	Lunch
Session 4: Glycobiology of infectious disease
Chair: Prof Ghislain Opdenakker, Head of the Department of Microbiology and Immunology Catholic University of Leuven
2.00 pm	Introduction
	Prof Ghislain Opdenakker, Head of the Department of Microbiology and Immunology Catholic University of Leuven
2.15 pm	Virology: Carbohydrate binding agents as antivirals
	Prof Dominique Schols, Rega Institute, University of Leuven, Belgium
2.45 pm	Glycans as major players during arterivirus entry in macrophages
	Prof Hans Nauwynck, Director Laboratory of Virology, Department Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Belgium; and Ir. Wander Van Breedam, Laboratory of Virology, Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Belgium
3.15 pm	Oral poster presentation: Myeloid cell modulation by a polyssacharide derivative averts susceptibility to a lethal virus infection
	Sandra Li, Rega Institute for Medical Research, Belgium
3.30 pm	Discussion
3.40 pm	Tea and coffee break
4.10 pm	Campylobacter - a tale of two glycosylation systems and implications for the development of novel glycoconjugate vaccines
	Prof Brendan Wren, Pathogen Molecular Biology Unit London School of Hygiene & Tropical Medicine, London, UK
4.40 pm	Oral poster presentation: Chemically disarming uropathogenic eschericha coli targeting their type 1 mediated cell adhesion
	Adinda Wellens, University of Brussels, Belgium
4.55 pm	Oral poster presentation: Recognition of blood group ABH type 1 determinants by the FedF adhesion of F18-fimbrated Escherichia coli
	Annelies Coddens, Ghent University, Belgium
5.10 pm	Discussion and completion of evaluation forms
Session 5: Cutting edge science lecture
Chair: Prof Oliver Fitzgerald, School of Medicine & Medical Science. Conway Institute, University College Dublin, Ireland
5.20 pm	Is it possible to correct the anergy of human tumor-infitrating lymphocytes
	Prof Pierre van der Bruggen, Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium
6.20 pm	End of day
7.30 pm	Guided tour of the senate
8.30 pm	Dinner at the Hilton Hotel
	Pre-booking for this dinner is required
Tuesday 15 September 2009
8.00 am	Registration
Session 6: Glycobiology of cancer
Chair: Prof Pauline M. Rudd, NIBRT Professor of Glycobiology, University College Dublin, Ireland
8.30 am	Plenary lecture "The glycan Shield of HIV - An antiviral and vaccine target"
	Prof Raymond Dwek, Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, UK
9.30 am	Introduction
	Prof Pauline M. Rudd
9.45 am	Applying new glcomics technologies to identify stem cell and cancer markers
	Prof Michael Pierce, Complex Carbohydrate Research Centre, University of Georgia, UGA Cancer Centre, University of Georgia, Athens, GA, USA
10.15 am	Pancreatic tumor-associated carbohydrate antigens as targets for anticancer therapeutic vaccines
	Prof Eric Mas, Faculte de Medecine-Timone Aix- Marseille, Université, Marseille, France
10.45 am	Tea and coffee break
11.15 am	Oral poster presentation: O-Glycan inhibitors mediate apoptosis and proliferation in colorectal cancer cell lines
	Anthony Corfield, University of Bristol, UK
11.30 am	Ribophorin II (RPN2) as a novel therapeutic target for drug resistant cancer
	Dr Takahiro Ochiya, Section for Studies on Metastasis, Japanese National Cancer Center Research Institute, Tokyo, Japan
12.00 pm	Altered glycosylation of serum proteins as tumour markers
	Dr Rosa Peracaula, Faculty of Sciences, University of Girona, Spain
12.30 pm	Oral poster presentation: Glycogenes mediate the development of colorectal cancer
	Anthony Corfield, University of Bristol, UK
12.45 pm	High throughput glycomics reveals serum markers for cancer and environmental factors that influence glycan processing.
	Prof Pauline M. Rudd
1.00 pm	Discussion
1.10 pm	Lunch
Session 7: Glycobiology diagnosis and treatment
Chair: Prof John Axford, St George's University of London, Director of the Sir Joseph Hotung Centre for Musculoskeletal Disorders London, UK
2.30 pm	Introduction
	Prof John Axford, St George's University of London, Director of the Sir Joseph Hotung Centre for Musculoskeletal Disorders London, UK
2.45 pm	Altered glycosylation in inflammatory bowel disease
	Prof J Rhodes, Professor of Medicine and Honorary Consultant Gastroenterologist, Royal Liverpool University Hospital
3.15 pm	Pathogen-related aspects of blood group antigens: The human Pk histo-blood group antigen and protection against HIV-1 infection
	Prof Martin L Olsson, The Regional Blood Center, Lund University Hospital, Sweden
3.45 pm	Oral poster presentation: An open-label dosing study to evaluate safety and affects of a dietary plant derived polysaccharide supplement on the N-glycosylation profile of serum glycoproteins in healthy subjects
	Azita Alavi, St George's University, London
4.00 pm	Discussion
4.10 pm	Tea and coffee break
4.40 pm	Neutralization of HIV-1 by redirection of naturally occurring anti glycan antibodies
	Prof Anders Vahlne, Professor in Clinical Virology, Division of Clinical Microbiology, Karolinska Institutet, Sweden
5.10 pm	Oral poster presentation: Multiple analytical approaches for the structural characterization of N-linked glycans on prostate specific antigen and prostatic and phospatase derived from prostatic secretions
	Richard Drake, Eastern Virgina Medical School, Norfolk, USA
5.25 pm	Oral poster presentation
5.40 pm	Discussion completion of evaluation forms
Session 8: End of meeting discussion
5.45 pm	Meeting highlights and where to next
	Prof Axford, Prof Rudd, Prof Opdenakker, Dr Kieda, Dr van Die and Prof Fitzgerald
6.30 pm	Close

The Royal Society of Medicine

9th Jenner Glycobiology and Medicine Symposium

Sunday 13 September 2009

Monday 14 September 2009

Tuesday 15 September 2009

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